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Studies & Research

Osteoarthritic Joint Pain

Joint Injection

Kon E, et al. (2010) Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions. Link

Khoshbin  A, et al. (2013)  The efficacy of platelet-rich plasma in the treatment of symptomatic knee osteoarthritis: a systematic review with quantitative synthesis. Link

Sánchez M, et al. (2012) Ultrasound-guided platelet-rich plasma injections for the treatment of osteoarthritis of the hip. Link

Centeno C, et al. (2016)  A dose response analysis of a specific bone marrow concentrate treatment protocol for knee osteoarthritis. Link

In Conjunction with Surgical Treatment

Fortier LA, et al. (2010) Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in an equine model. Link

Milano G, et al. (2010) The effect of platelet rich plasma combined with microfractures on the treatment of chondral defects: an experimental study in a sheep model. Link

Buda R, et al. (2015) One-step bone marrow-derived cell transplantation in talar osteochondral lesions: mid-term results. Link

Meniscus or Ligament Injuries

Foster TE, et al. (2009) Platelet-rich plasma: from basic science to clinical application. Link

Murray MM, et al. (2009) Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen–platelet-rich plasma scaffold. Link

Braun HJ, et al. (2013) The Use of PRP in ligament and meniscal healing. Link

Yu H, et al. (2015) Meniscus repair using mesenchymal stem cells – a comprehensive review. Link

Cook JL, et al. (2016) Multiple injections of leukoreduced platelet rich plasma reduce pain and functional impairment in a canine model of ACL and meniscal deficiency. Link

Muscle and Tendon Injuries

Lateral Epicondylitis

Peerbooms JC, (2010) Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-Year follow-up. Link


Gosens T, et al. (2011) Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up. Link

Mishra A, et al. (2014) Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trial of 230 patients. Link

Patellar Tendonitis

Cervellin M, et al. (2012) Autologous platelet-rich plasma gel to reduce donor-site morbidity after patellar tendon graft harvesting for anterior cruciate ligament reconstruction: a randomized, controlled clinical study. Link

Di Matteo B, et al. (2015) Platelet-rich plasma: evidence for the treatment of patellar and Achilles tendinopathy—a systematic review. Link

Pascual-Garrido C, et al. (2012) Treatment of chronic patellar tendinopathy with autologous bone marrow stem cells: a 5-year followup. Link

Rotator Cuff Tears

Randelli P, et al. (2011) Platelet rich plasma in arthroscopic rotator cuff repair: a prospective RCT study, 2-year follow-up. Link

Hernigou P, et al. (2014) Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study. Link

Achilles Tendinopathy

Sanchez M, et al. (2007) Comparison of surgically repaired Achilles tendon tears using platelet rich fibrin matrices. Link


Stein BE, et al. (2015) Outcomes of acute Achilles tendon rupture repair with bone marrow aspirate concentrate augmentation. Link


Galasso O, et al. (2008) Expandable intramedullary nailing and platelet rich plasma to treat long bone non-unions. Link



Sampson S, et al. (2008) Platelet rich plasma injection grafts for musculoskeletal injuries: a review. Link


Cosmetic Surgery

Man D, et al. (2001) The use of autologous platelet-rich plasma (platelet gel) and autologous platelet-poor plasma (fibrin glue) in cosmetic surgery. Link

Cervelli V, et al. (2009) Application of platelet-rich plasma in plastic surgery: clinical and in-vitro evaluation. Link

Redaelli A, et al. (2010) Face and neck revitalization with platelet-rich plasma (PRP): clinical outcome in a series of 23 consecutively treated patients. Link

Sclafani AP, and SA McCormick. (2012)  Induction of dermal collagenesis, angiogenesis, and adipogenesis in human skin by injection of platelet-rich fibrin matrix.  Link

Lee JW, et al. (2011) The Efficacy of autologous platelet rich plasma combined with ablative carbon dioxide fractional resurfacing for acne scars: A Simultaneous Split-Face Trial. Link

Cho JM, et al. (2011) Effect of platelet-rich plasma on ultraviolet b-induced skin wrinkles in nude mice. Link

Shin MK, et al. (2012) Platelet-rich plasma combined with fractional laser therapy for skin rejuvenation. Link



Pettine K, et al. (2015) Percutaneous Injection of Autologous Bone Marrow Concentrate Cells Significantly Reduces Lumbar Discogenic Pain Through 12 Months. Link

Pettine K, et al. (2016) Treatment of discogenic back pain with autologous bone marrow concentrate injection with minimum two year follow-up. Link

Monfett M, et al. (2016) Intradiscal platelet-rich plasma (PRP) injections for discogenic low back pain: an update. Link

Wound Care

Hom DB, et al. (2007) The healing effects of autologous platelet gel on acute human skins wounds. Link

Driver VR, et al. (2006) A prospective, randomized, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers. Link

Kazakos K, et al. (2009) The use of autologous PRP gel as an aid in the management of trauma wounds. Link

Carter MJ, et al. (2011) Use of platelet-rich plasma gel on wound healing: a systematic review and meta-analysis. Link

Saad Setta, H, et al. (2011) Platelet-rich plasma versus platelet-poor plasma in the management of chronic diabetic foot ulcers: a comparative study. Link

Dabiri G, et al. (2013) The emerging use of bone marrow-derived mesenchymal stem cells in the treatment of human chronic wounds. Link

Oral and Maxillofacial Surgery

Marx RE. Platelet-rich plasma: evidence to support its use. Link

Sammartino G, et al. (2005) Use of autologous platelet-rich plasma in periodontal defect treatment after extraction of impacted mandibular third molars. Link

Bajaj P, et al. (2013) Comparative evaluation of autologous platelet-rich fibrin and platelet-rich plasma in the treatment of mandibular degree II furcation defects: a randomized controlled clinical trial. Link

Peripheral Vascular Disease

Tateishi-Yuyama  E, et al. (2002) Therapeutic angiogenesis for patients with limb ischemia by autologous transplantation of bone-marrow cells: a pilot study and a randomized controlled trial. Link

Bartsch T, et al. (2007) Transplantation of autologous mononuclear bone marrow stem cells in patients with peripheral arterial disease (the TAM-PAD study). Link

Amann B, et al. (2009) Autologous bone marrow cell transplantation increases leg perfusion and reduces amputations in patients with advanced critical limb ischemia due to peripheral artery disease. Link

Fadnini GP, et al. (2010) Autologous stem cell therapy for peripheral arterial disease: Meta-analysis and systemic review of the literature. Link

Molavi B, et al. (2016) Safety and Efficacy of Repeated Bone Marrow Mononuclear Cell Therapy in Patients with Critical Limb Ischemia in a Pilot Randomized Controlled Trial. Link

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